MONTHLY RESEARCH UPDATE Long-term follow-up of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linking to halt the progression of keratoconus
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With our background in clinical ophthalmic research, mainly of the anterior eye, Bausch and Lomb have asked us to produce an independent report of some of the interesting findings coming out of the research journals each month. As a busy practitioner, this should allow you to keep more up-to-date with cutting edge clinical research and allow you to locate the articles when you want to know more about a topic highlighted.
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A randomised, prospective study to investigate the efficacy of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linkage to halt the progression of keratoconus.
AIMS A blind, randomised, prospective, bilateral study to investigate the efficacy of riboflavin/ultraviolet A corneal collagen cross-linkage to halt the progression of keratoconus. METHODS 24 patients with early/moderate bilateral keratoconus with recent progression were recruited. One eye was randomly assigned to undergo collagen cross-linkage following epithelial removal with riboflavin 0....
متن کاملCorneal collagen cross-linking (CXL) in thin corneas
Corneal collagen cross-linking (CXL) is a therapeutic procedure aiming at increasing the corneal stiffness in the keratoconus eyes by induction of cross-links within the extracellular matrix. It is achieved by ultraviolet-A (370 nm) irradiation of the cornea after saturation with the photosensitizer riboflavin. In the conventional CXL protocol, a minimum de-epithelialized corneal thickness of 4...
متن کاملRiboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus.
PURPOSE In animal eyes, a significant increase in corneal biomechanical stiffness has been found after collagen crosslinking by combined riboflavin/ultraviolet-A (UVA) treatment. The aim of the present study was to evaluate the clinical usefulness of riboflavin/UVA-induced collagen crosslinking for bringing the progression of keratoconus to a halt. DESIGN Prospective, nonrandomized clinical p...
متن کاملLong-term follow-up of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linking to halt the progression of keratoconus.
AIMS To determine long-term efficacy of riboflavin/ultraviolet A corneal cross-linking (CXL). METHODS Thirty patients (30 eyes) who had undergone CXL following epithelial removal 4-6 years previously were examined. RESULTS At 1-year mean, spherical equivalent error (SEQ) increased by +0.72 dioptres (D) (p<0.002), corrected distance visual acuity (CDVA) improved (p<0.005), mean simulated ker...
متن کاملCorneal collagen cross-linking: a review.
The aim was to review the published literature on corneal collagen cross-linking. The emphasis was on the seminal publications, systemic reviews, meta-analyses and randomized controlled trials. Where such an evidence did not exist, selective large series cohort studies, case controlled studies and case series with follow-up preferably greater than 12 months were included. Riboflavin/Ultraviolet...
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